Regístrese Buscar F.A.Q. Lista de Miembros Grupos de Usuarios Conectarse  
Responder al Tema GENES HLA Y NO HLA EN LA ENFERMEDAD DE BEHÇET
GENES HLA Y NO HLA EN LA ENFERMEDAD DE BEHÇET
goran
Administrador/a
Administrador/a

Registrado: 14 Abr 2008
Mensajes: 445
Responder citando
Research article

HLA and non-HLA genes in Behcet s disease: a multicentric study in the Spanish population



Agradecer como siempre la inestimable ayuda, colaboración y trabajo de los doctores Norberto Ortego y Genaro Graña, tanto por su dedicación a la enfermedad como por su trato hacia la Asociación.


Marco Antonio Montes-Cano, Marta Conde-Jaldón, José Raul García-Lozano, Lourdes Ortiz-Fernández, Norberto Ortego-Centeno, María Jesús Castillo-Palma, Gerard Espinosa, Genaro Graña-Gil, Miguel Angel González-Gay, Ana Celia Barnosi-Marín, Roser Solans, Patricia Fanlo, Teresa Camps, Santos Castañeda, Juan Sánchez-Bursón, Antonio Núñez-Roldán, Javier Martín and María Francisca González-Escribano


Abstract (provisional)

Introduction

According to genome wide association (GWA) studies as well as candidate gene approaches, Behcet s disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of this study were to further investigate the influence of the HLA region in BD and to explore the relationship with non-HLA genes recently described to be associated in other populations.

Methods

This study included 304 BD patients and 313 ethnically matched controls. HLA-A and HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag single nucleotide polymorphisms (SNPs) located outside of the HLA-region, previously described associated with the disease in GWA studies and having a minor allele frequency in Caucasians greater than 0.15 were genotyped using TaqMan assays. Phenotypic and genotypic frequencies were estimated by direct counting and distributions were compared using the chi2 test.

Results

In addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 was found to be protective. Other HLA-A and B specificities were suggestive of association with the disease as risk (A*02 and A*24) or protective factors (A*03 and B*5Cool. Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population.

Conclusion

Different HLA specificities are associated with Behcet disease in addition to B*51. Other non-HLA genes, such as IL23R and IL-10, play a role in the susceptibility to the disease.

Fuente:ARTHRITISRESEARCH.COM
Ver perfil del usuarioBuscar todos los mensajes de goranEnviar mensaje privado
guayyyyyyyyyyyyyyyyyy
GORI
Bestia del Foro
Bestia del Foro

Registrado: 26 Abr 2010
Mensajes: 713
Responder citando
me encanto ya esta mas cerca el acabar con nuestro sufrimiento
Ver perfil del usuarioBuscar todos los mensajes de GORIEnviar mensaje privadoMSN Messenger
GORI
Bestia del Foro
Bestia del Foro

Registrado: 26 Abr 2010
Mensajes: 713
Responder citando
esto a escrito lo que le a dao la gana jejejejeje quise decir que ya esta mas cerca acabar con nuestro sufrimiento
Ver perfil del usuarioBuscar todos los mensajes de GORIEnviar mensaje privadoMSN Messenger
GENES HLA Y NO HLA EN LA ENFERMEDAD DE BEHÇET
No puede crear mensajes
No puede responder temas
No puede editar sus mensajes
No puede borrar sus mensajes
No puede votar en encuestas
Todas las horas están en GMT + 2 Horas  
Página 1 de 1  

  
  
 Responder al Tema  
Powered by phpBB © phpBB Group
Design by phpBBStyles.com | Styles Database.
Content © - Asociación Española de la Enfermedad de Behcet -